New organophosphorus compounds: cholinesterases inhibition, cytotoxicity and lethal dose.
نویسندگان
چکیده
منابع مشابه
Interactions of cyclodextrins and their derivatives with toxic organophosphorus compounds
The aim of this review is to provide an update on the current use of cyclodextrins against organophosphorus compound intoxications. Organophosphorus pesticides and nerve agents play a determinant role in the inhibition of cholinesterases. The cyclic structure of cyclodextrins and their toroidal shape are perfectly suitable to design new chemical scavengers able to trap and hydrolyze the organop...
متن کاملSensors 2001, 1, 60-74
Biosensors are sensitive and can be used as disposable sensors for environmental control. These biosensors are based either on inhibition of acyl cholinesterases acetylcholinesterase or butyrylcholinesterase) by organophosphorus compounds or on inhibition of enzymes phosphatases (acid or alkaline) or on direct detection of organophosphorus compounds by organophosphorus hydrolase. The state-of-t...
متن کاملEsterases Reacting with Organophosphorus Compounds
The sixty-seven papers in this book are grouped under the following chapters: Esterase Structures, Catalytic Properties of Cholinesterases, Catalytic Properties of Paraoxonases and Related Esterases, Biology of Cholinesterases, Biology of Paraoxonases and Related Esterases, Toxicity and Degradation of Organophosphorus Compounds, Neuropathy Target Esterase, and Miscellaneous. The chapters are pr...
متن کاملFluorescent Chemosensors for Toxic Organophosphorus Pesticides: A Review
Many organophosphorus (OP) based compounds are highly toxic and powerful inhibitors of cholinesterases that generate serious environmental and human health concerns. Organothiophosphates with a thiophosphoryl (P=S) functional group constitute a broad class of these widely used pesticides. They are related to the more reactive phosphoryl (P=O) organophosphates, which include very lethal nerve ag...
متن کاملOrganophosphorus compounds and esterases: current research topics concerning the toxicity of and protection against organophosphates.
This brief review describes the reactions of organophosphorus compounds with cholinesterases, neuropathy target esterase, and phosphoric triester hydrolases with respect to their toxicity. It also describes antidotes, protectors, and decontaminating agents against organophosphates.
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ورودعنوان ژورنال:
- Clinica chimica acta; international journal of clinical chemistry
دوره 389 1-2 شماره
صفحات -
تاریخ انتشار 2008